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Complementary and Alternative Medicine

Complementary and alternative medicine (CAM) may have a role in breast cancer care after a breast cancer diagnosis. Clinical trials are investigating which CAM therapies are effective during treatment or can improve quality of life for breast cancer survivors.

Broccoli Sprout Extract For Treating ER+ Breast Cancer

A Pilot Study of Broccoli Sprout Extract in Patients With Invasive Breast Cancer (NCT01753908)

Summary

Broccoli is a member of the brassicales family. Studies have found that plants and flowers that are part of this family contain chemicals, called isothiocyanates, that may prevent or slow the growth of certain cancers. This study is comparing broccoli sprout extract to a placebo in order to see whether broccoli sprout extract alters biological markers associated with cancer cell growth when it is given to postmenopausal women with early-stage ER+ breast cancer for two weeks prior to the start of their cancer treatment.

Vitamin D Before Surgery for Breast Cancer

Vitamin D and Breast Cancer in Obesity: Therapeutic Trials (NCT01472445)

Summary

Vitamin D is an essential nutrient for bone health, calcium absorption, and immune function. Researchers believe that vitamin D may have an effect on breast cancer cells, and that this effect may be even greater in women with breast cancer who are obese. This study will investigate whether giving vitamin D prior to surgery can change the tumor's gene expression pattern from high-risk to low-risk. The researchers will also investigate whether these pattern changes occur in the same ways in obese and non-obese women. To be eligible, participants must be planning to have surgery for breast cancer but have not yet had any treatment.

Green Tea for Newly-Diagnosed DCIS

A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ (DCIS) (NCT01060345)

Summary

Studies have shown that women with ductal carcinoma in situ (DCIS) have inflammation in the breast tissue surrounding their DCIS. This finding supports the idea that there is a link between inflammation and cancer. Researchers are studying green tea because both laboratory and epidemiology studies suggest that green tea may have anti-cancer and anti-inflammatory effects. The purpose of this study is to find molecular signs (biomarkers) that will help researchers better understand the role of green tea as an anti-cancer and anti-inflammation agent in women with newly-diagnosed ductal carcinoma in situ (DCIS).

Diindolylmethane as a Breast Cancer Treatment

Evaluation of Diindolylmethane Supplementation to Modulate Tamoxifen Efficacy in Breast Cancer The Diindolylmethane Efficacy Study (NCT01391689)

Summary

Cruciferous vegetables, such as broccoli, cabbage, Brussels sprouts, cauliflower and kale, produce a natural compound called diindolylmethane (DIM) in the body during the digestion process. Studies have shown that DIM can slow the growth of tumor cells. It also may be able to kill cancer cells by preventing the growth of the blood vessels tumors need to grow and spread, and acting like an anti-estrogen therapy in hormone-sensitive tumors. For these reasons, scientists think that DIM may be an effective breast cancer treatment. The goal of this trial is to compare the safety and effectiveness of DIM to a placebo in breast cancer patients and in women at high risk of developing breast cancer. To be eligible, participants must be receiving or planning to receive tamoxifen.
This is a Phase II-III trial

The Effect of Vitamin D & Celebrex® on Breast Cancer Biomarkers

Breast Cancer Prevention Using Synergistic Prostaglandin Inhibitors (The Vitamin D/Celecoxib Study) (NCT01425476)

Summary

Some studies have suggested that inflammation in the body may increase breast cancer risk. Vitamin D helps the body absorb and maintain the right amount of calcium in the blood. It also helps control cell growth and reduce inflammation. Celecoxib (Celebrex®) is a drug that reduces inflammation by inhibiting an enzyme called COX-2. The purpose of this study is to determine if vitamin D alone or in combination with Celebrex decreases levels of certain biological markers (biomarkers) thought to be related to breast cell changes and breast cancer risk. To be eligible, a woman must be at an increased risk for developing breast cancer because she has been diagnosed with precancerous breast changes, has a five-year Gail Model risk score that is 1.66% or higher, or has a personal or family history of breast cancer.
This is a Phase I-II trial

Flaxseed to Reduce Risk in High-Risk Premenopausal Women

Flaxseed Lignan as a Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer (NCT01276704)

Summary

Secoisolariciresinol digluscside (SDG) is a lignan (plant-based estrogen) that is found in flaxseed. Laboratory studies have shown that plant-based estrogens can fit into the estrogen receptor, where they act as weak estrogens in the breast and uterus. By blocking the estrogen receptor, plant-based estrogens may be able to protect cells from the stronger estrogens produced by a woman's body. Brevail® is a supplement that contains SDG made from flaxseed. The purpose of this study is to see whether Brevail® reduces the risk of breast cancer in high-risk premenopausal women. To be eligible, women must be high risk due to one of the following: a first or second degree relative with breast cancer diagnosed before the age of 60; a prior history of atypical hyperplasia, LCIS, or multiple prior breast biopsies regardless of histology; high mammographic density; prior or current evidence of atypia; or a known BRCA1 or 2 mutation.
This is a Phase II trial

Effect of Tumeric on Breast Tissue in Obese, High-Risk Women

Nanoemulsion Curcumin for Obesity, Inflammation and Breast Cancer Prevention - a Pilot Trial (NCT01975363)

Summary

Laboratory studies suggest that tumeric (curcumin) may have anti-cancer effects. This may be because tumeric can reduce inflammation, which has been linked to cancer growth. Researchers think that tumeric may reduce inflammation in fat tissue and breast tissue, which may decrease breast cancer risk. This pilot study is looking at the effect that tumeric has on the breast tissue of obese women who are at high risk for breast cancer.

Flaxseed for Risk Reduction in High-Risk Premenopausal Women

Flaxseed in Preventing Breast Cancer in Premenopausal Women at Risk of Developing Breast Cancer (NCT00794989)

Summary

Flaxseed is a good source of lignans, a compound that may act like a weak estrogen. Some researchers believe that eating these weak estrogens may keep your body from producing its strong estrogens, which, in turn, may reduce breast cancer risk. Other researchers believe that it may not be beneficial for women to consume any substances that act like weak estrogens. The goal of this trial is to determine the effect of flaxseed on the development of breast cancer. To be eligible, women must be at high risk of developing breast cancer because they have previously been diagnosed with stage I breast cancer or ductal carcinoma in situ (DCIS) and it has been more than one year since they have completed hormone therapy and/or chemotherapy; have been diagnosed with lobular carcinoma in situ (LCIS); ductal or lobular hyperplasia; or have a greater than 20 percent risk of developing breast cancer according to the Gail or Claus risk models.

Exercise Programs in Healthy, High-Risk Young Women

Exercise Programs in Healthy Young Women at Increased Risk of Developing Breast Cancer (NCT00892515)

Summary

Studies suggest that exercise may decrease a woman's risk of developing breast cancer. It is not yet known whether certain types of exercise are more likely to reduce risk than others, or whether low-intensity exercise and high-intensity exercise have the same effects. The goal of this trial is to compare the effects of a low-intensity and high-intensity exercise program on hormone levels, breast density, and body composition in healthy women between the ages of 18 and 35 who are at increased risk of developing breast cancer.

Cognitive-Behavioral Therapy for Insomnia After Treatment

Cognitive-Behavioral Therapy for Chronic Insomnia After Breast Cancer Treatment (NCT00672217)

Summary

Many cancer patients experience persistent difficulty falling asleep or staying asleep. Studies have shown that psychological and behavioral factors play an important role in insomnia. Cognitive behavioral therapy (CBT) is an effective treatment for insomnia that provides an alternative to sleeping pills. The CBT approach aims to change the thoughts and actions that interfere with the ability to get restful sleep. The goal of this study is to examine the effects of CBT on women who experience long-term difficulty with sleeping after cancer treatment. Participants must have completed radiation or chemotherapy within three years of beginning this study.

Comparing Therapies for Depression Related to Breast Cancer

Interpersonal Therapy for Depression in Breast Cancer (NCT01191580)

Summary

Depression can negatively affect a cancer patient's adherence to treatment, survival, symptom management, psychosocial functioning, and quality of life. The goal of this trial is to compare the effectiveness of three different types of therapy (Interpersonal Psychotherapy, Problem-Solving Therapy, and Brief Supportive Psychotherapy) in improving depressive symptoms, psychosocial functioning, and quality of life among patients with breast cancer who have been diagnosed with Major Depressive Disorder.
This is a Phase IV trial

Exercise During Treatment for DCIS and Early-Stage Disease

Prescriptive Exercise Intervention During Active Treatment for Early Stage Breast Cancer Patients: A Breast Cancer Rehabilitation & Exercise Laboratory (NCT01157130)

Summary

Studies suggest that exercise may reduce the risk of a breast cancer recurrence as well as improve quality of life. Precisely how exercise reduces recurrence risk is not fully understood. However, scientists think that exercise during breast cancer treatment may affect proteins and hormones, such as insulin and estrogen, that are related to cancer growth. The goal of this trial is to determine the effect that exercise instruction has on exercise levels, biological measures, and psychosocial factors. To be eligible, participants must have been recently diagnosed with DCIS or early-stage breast cancer and not yet begun treatment. In addition, participants must be planning to receive treatment that includes chemotherapy and/or radiation.

Counseling for Breast Cancer Patients Age 70 and Over

Pilot of a Geriatric Group Psychoeducational Intervention for Elderly Patients With Cancer (NCT00984321)

Summary

Many women seek counseling after a breast cancer diagnosis. This counseling program was developed to meet the specific needs of older cancer patients, who often find themselves facing problems related to both cancer and aging. The goal of this trial is to see whether a counseling program can help reduce depression, anxiety, and feelings of loneliness and isolation as well as improve the quality of life of older women with breast cancer. To be eligible, participants must be receiving treatment at Memorial Sloan-Kettering Cancer Center.

Yoga During Radiation Therapy

Biobehavioral Effects of Yoga for Women With Breast Cancer Undergoing Radiotherapy (NCT01202851)

Summary

Researchers believe that mind-body interventions can be beneficial to women undergoing breast cancer treatment. Yoga is a mind-body intervention that has been shown to reduce fatigue as well as improve quality of sleep, physical vitality, and overall quality of life in women being treated for breast cancer. This study will compare the effectiveness of a yoga program with a stretching/relaxation program for improving the physical and emotional well-being of women with DCIS or Stage I-III breast cancer who are undergoing radiation treatment after surgery. The study will also include a group of women who will not take part in either the yoga or stretching/relaxation program. To be eligible, participants must be planning to receive radiation therapy following breast surgery. In addition, participants must not have practiced yoga in the year prior to breast cancer diagnosis.
This is a Phase III trial

Massage to Reduce Anxiety Before Breast Cancer Surgery

Utility of Preoperative Massage in Breast Surgery Patients (NCT01667328)

Summary

It is not uncommon for patients to report feeling anxious prior to their breast cancer surgery. Studies have demonstrated that massage can offer some health benefits for people with cancer. Massage has also been found to be help reduce anxiety. This study is investigating whether breast cancer patients who receive massage therapy by a licensed massage therapist before surgery have lower anxiety levels than those who do not receive massage therapy.

Swedish Massage Therapy to Reduce Cancer-Related Fatigue in Breast Cancer Survivors

Efficacy of Swedish Massage Therapy on Cancer-related Fatigue in Cancer (NCT01926678)

Summary

Many cancer survivors experience cancer-related fatigue. Studies suggest that individuals whose immune system is continually activated may experience more fatigue. Decreasing this immune system activation may help to reduce symptoms of cancer-related fatigue. Swedish Massage Therapy is a type of massage that may help reduce immune system activation. This study is comparing the effect that Swedish Massage Therapy, light touch therapy, and and being put on a wait list for massage therapy have on the immune system of breast cancer survivors who are experiencing cancer-related fatigue.
This is a Phase II trial

Acupressure for Persistent Cancer Related Fatigue

Acupressure for Persistent Cancer Related Fatigue (NCT01281904)

Summary

Persistent Cancer-Related fatigue (PCRF), a state of being tired or weary, is one of the most common and distressing symptoms breast cancer survivors may experience. There currently are few treatment options for PCRF. Acupressure is a technique derived from acupuncture, a component of Traditional Chinese Medicine. In acupressure, physical pressure is applied to acupuncture points by the hand or elbow or with a special device. Pilot studies suggest that self-administered acupressure may be a promising treatment for PCRF. The goal of this study is to determine the benefit of acupressure for treating PCRF in breast cancer survivors who have completed cancer treatments. (Individuals on anti-estrogen therapy, such as tamoxifen or an aromatase inhibitor, can also participate.) To be eligible, participants must have a complaint of persistent, moderate to severe fatigue despite standard treatment.
This is a Phase II-III trial

Couples Counseling for Breast Cancer Patients

Couple-Focused Group Intervention for Women With Early-Stage Breast Cancer (NCT00940277)

Summary

Breast cancer treatment can be physically and emotionally demanding for both patients and their partners. The goal of this study is to determine the value of two counseling interventions developed to reduce the psychological distress on patients and their partners during and after the breast cancer experience. Both patients and their partners will participate in the counseling interventions. Couples must be married or co-habitating.

Acupuncture to Reduce Chemotherapy Related Side Effects in Early-Stage Breast Cancer

The Efficacy of Acupuncture in Treating Chemotherapy Side Effects in Breast Cancer Patients (NCT01996410)

Summary

Acupuncture is a treatment that involves inserting sterile, hair-thin needles into specific points on the skin. Studies have found that acupuncture can help relieve fatigue, hot flashes, nausea, vomiting, and pain. Researchers believe this is because acupuncture stimulates the nervous system. This study is investigating whether acupuncture can reduce symptoms associated with chemotherapy, such as nausea, vomiting, fatigue, anxiety, anorexia, pain, disturbed sleep, shortness of breath, dry mouth, depression, and peripheral neuropathy. To be eligible, a patient must be planning to receive chemotherapy to treat stage I - III breast cancer.

Diet and Exercise Program for Overweight Survivors

Preventing Breast Cancer Recurrence Through a Tailored Lifestyle Intervention. (NCT01630499)

Summary

Breast cancer survivors who are overweight or obese are at greater risk for having a breast cancer recurrence as well as for other health problems, like heart disease. The purpose of this study is to compare a tailored nutrition, physical activity, and behavioral weight management program for breast cancer survivors against a widely available commercial weight management program. The researchers are interested in learning whether an intervention tailored to the unique psychological, nutritional and physical needs of breast cancer survivors will provide superior physiological and psychological benefits than the existing commercial program. To be eligible, participants must have a BMI of 27 to 45.

Acupuncture To Treat Chemotherapy-Induced Neuropathy

Acupuncture to Prevent Chemotherapy Dose Reduction Due to Chemotherapy-induced Peripheral Neuropathy in Breast and Colorectal Cancer Patients (NCT01881932)

Summary

Peripheral neuropathy is a common side effect of chemotherapy. It usually includes pain, tingling, and numbness in the fingers and toes. This may cause a patient to receive a lower dose or a change of medication. Acupuncture, a technique used in traditional Chinese medicine, is commonly used to treat pain. Previous studies suggest that acupuncture could be effective in controlling neuropathy. This study will determine the effectiveness of using acupuncture to manage the pain, tingling and numbness caused by chemotherapy and if this treatment can help prevent reducing the dose of chemotherapy. To be eligible, participants must be receiving chemotherapy that includes a taxane or oxaliplatin and be experiencing symptoms of neuropathy.

Ayurveda: An Alternative Approach to Cancer Survivorship

A Whole Systems Approach to the Study of Ayurveda for Cancer Survivorship, Project II (NCT01488123)

Summary

Ayurveda medicine is a healing oriented approach to care that incorporates both conventional and alternative therapies. For breast cancer survivors who experience a reduced quality of life as result of their diagnosis and treatment, it may provide an alternative option for post-treatment care. Ayurveda, a whole system of medicine that originated in the Indian subcontinent, has its own system of diagnostics and therapeutics, and among its strengths are wellness and prevention. The purpose of this study is to determine whether a four-month Ayurvedic intervention will improve the quality of life of recent breast cancer survivors. To be eligible, participants must be over 1 month and less than 12 months beyond the completion of primary therapy (surgery, radiation, and chemotherapy). Participants must also have received chemotherapy and be in complete remission.

BEAT Exercise Program for Early-Stage Survivors

Enhancing Physical Activity Adherence After Breast Cancer Diagnosis: Randomized Trial (NCT00929617)

Summary

Studies suggest that physical activity may reduce a woman's risk of a breast cancer recurrence as well as improve quality of life. Exercise can also help with weight management and the control other health conditions. However, it is not uncommon for breast cancer survivors to become less active during their treatment and/or to not return to the level of activity they had prior to their diagnosis. The "BEAT" exercise program is designed to encourage breast cancer survivors to increase their physical activity. The goal of this study is to determine if women who take part in the "BEAT" exercise program become more physically active and have better health outcomes than women not in the program. To be eligible, participants must have completed treatment (except hormone therapy, if applicable) and must currently not do more than 20 minutes of physical activity two days per week.

Glutamine for Chemotherapy-Related Neuropathy

A Randomized Placebo-Controlled Trial of Glutamine to Reduce the Signs and Symptoms of Peripheral Neuropathy in Breast Cancer Patients With a Mild Peripheral Neuropathy Receiving Paclitaxel Chemotherapy (NCT00195013)

Summary

Peripheral neuropathy is a common side effect of chemotherapy. It usually includes numbness, tingling, or painful feelings in the fingers and toes. Previous research has shown that the amino acid glutamine may help to prevent or reduce the development of these symptoms. The goal of this study is to further investigate the effect of glutamine on peripheral neuropathy and to figure out why people experience peripheral neuropathy after receiving chemotherapy. Participants must be receiving or have recently completed paclitaxel (Taxol®) or nab-paclitaxel (Abraxane®) chemotherapy.
This is a Phase III trial

In-Home Foot Reflexology for Breast Cancer Patients

Home-Based Symptom Management Via Reflexology for Breast Cancer Patients (NCT01582971)

Summary

Reflexology is a complementary medicine technique that involves applying firm pressure to certain parts of the sole of the foot. Its practitioners believe that there are areas on the foot that correspond to areas of the body, and that manipulating these areas can improve health. The purpose of this project is to see if weekly foot reflexology that is delivered by a friend or family member improves the quality of life of women who are receiving chemotherapy or hormone therapy as part of their breast cancer treatment.

Multi-Media Support Program for Post-Treatment Survivors

Multi-Media Imagery Program for Breast Cancer Patients (Phase II) (NCT01034215)

Summary

Many women who have been treated for early stage breast cancer experience long-term effects, such as chemobrain, fatigue, sleep deprivation, stress, anxiety, depression, and post-traumatic stress disorder (PTSD). The goal of this study is to evaluate the effectiveness of a multi-media program, called "Envision the Rhythms of Life," that aims to reduce stress and improve quality of life. The program uses animation, PowerPoint, manuals, art, and audio-art. To be eligible, it must be at least six weeks since the completion of surgery, radiation, and/or IV-delivered chemotherapy.
This is a Phase II trial

Electroacupuncture to Reduce Nerve Pain Caused by Taxol®

Randomized Sham Controlled Trial of Weekly Electro-acupuncture for the Prevention of Taxane Induced Myalgias and Neuropathy (NCT01163682)

Summary

The chemotherapy drug paclitaxel (Taxol®) is a widely used effective breast cancer treatment. However, one of its common side effects is nerve and muscle pain. Acupuncture is a technique used in traditional Chinese medicine that involves the insertion of hair-thin needles into various points in the skin. Electroacupuncture is a form of acupuncture in which pairs of acupuncture needles are attached to a device that generates electrical pulses between them. Studies have shown that it can help to relieve pain. This trial is investigating whether giving electroacupuncture during paclitaxel treatment can help to prevent or decrease nerve pain. To be eligible, participants must be planning to receive weekly paclitaxel for 12 weeks after surgery for early-stage breast cancer and must never have received acupuncture treatment.
This is a Phase I trial

Acupuncture for Joint Pain Caused by an Aromatase Inhibitor

Randomized Blinded Sham- and Waitlist-Controlled Trial of Acupuncture for Joint Symptoms Related to Aromatase Inhibitors in Women With Early Stage Breast Cancer (NCT01535066)

Summary

Aromatase inhibitors are used to treat hormone-sensitive tumors in postmenopausal women. One of the most common side effects associated with these drugs is joint pain and stiffness. A small study found that acupuncture can be an effective treatment in early stage breast cancer patients on an aromatase inhibitor experiencing joint pain and stiffness. This larger study is being conducted to confirm those results. It is comparing the effects of acupuncture, sham acupuncture or being placed on a wait list on joint pain in women with early-stage breast cancer taking an aromatase inhibitor. Patients not assigned to the acupuncture group will receive acupuncture at the end of the study.
This is a Phase III trial

Black Cohosh Before Surgery for Ductal Carcinoma in Situ

A Pilot Pre-operative Window Trial of Black Cohosh in Women With Ductal Carcinoma in Situ (NCT01628536)

Summary

Black cohosh is an herb that is sold as a dietary supplement to treat hot flashes and other menopausal symptoms. Researchers are investigating whether it could also play a role in breast cancer treatment. This pilot study is investigating whether black cohosh can reduce the overall size and aggressiveness of DCIS when it is given prior to surgery.

Exercise or Mind-Body Program Before Surgery

The Preoperative Health & Body Study (NCT01516190)

Summary

This study is designed to look at the changes that occur in women who take part in exercise and mind-body programs between their breast cancer diagnosis and breast surgery. The investigators are interested in seeing if these programs can decrease stress and anxiety and improve mood and quality of life during this time. The investigators are also interested in looking at whether this type of short program affects certain markers in breast cancer cells, such as their growth and death rates, or in blood hormones such as insulin, which have been linked to breast cancer development. To be eligible, participants must not be planning to receive chemotherapy or hormone therapy before surgery.

Mind-Body Program for Metastatic Cancer Patients

Evaluation of Mind-Body Groups on the Quality of Life of Cancer Patients (NCT00179387)

Summary

Pain, fatigue, anxiety, depression, nausea, sexual impairment, body image disturbance, and relationship strains are all potential "side-effects" of living with cancer and its treatment. Behavioral interventions have shown some success in relieving distress and improving quality of life among cancer patients. The purpose of this study is to find out if mind-body psychotherapy groups can help improve the physical and emotional well-being of people facing cancer. Participants must be on active cancer treatment.

Yoga-Based Cancer Rehabilitation Program

Evaluation of a Yoga-Based Cancer Rehabilitation Program (NCT00179348)

Summary

Yoga may help to improve quality of life for individuals with cancer because it incorporates elements of relaxation, social support, and exercise. Benefits of yoga include improved mood, energy, memory, concentration, physical fitness, and decreased pain. This study compares a 12-week yoga intervention to standard care on quality of life among patients with early-stage breast, lung, and colorectal cancer. Participants must have been diagnosed with new or recurrent cancer within the past 5 years.

Omega-3 Fatty Acids to Reduce Paclitaxel-Related Pain

A Pilot Randomized, Placebo Controlled, Double Blind Study of Omega-3 Fatty Acids to Prevent Paclitaxel Associated Acute Pain Syndrome (NCT01821833)

Summary

Omega-3 fatty acids are nutrients that are essential for good health. Omega-3 fatty acids are not made by the body; they are obtained through foods or supplements. Paclitaxel (Taxol) is a chemotherapy drug commonly used to treat breast cancer. One of it most common side effects is pain. Studies suggest that omega-3 fatty acids may help decrease Taxol-related pain. This study is looking at whether omega-3 fatty acids are better than a placebo for reducing pain. To be eligible, participants must be scheduled to receive treatment with the chemotherapy drug paclitaxel.

Coenzyme Q10 to Reduce Heart Damage from Adriamycin®

Phase I Randomized, Placebo-Controlled, Cross-Over, Dose-Finding Pharmacokinetic Study of CoQ10 During One Cycle of Doxorubicin Treatment for Breast Cancer (NCT00976131)

Summary

Many women with breast cancer receive a chemotherapy regimen that includes the drug doxorubicin (Adriamycin®). However, women given doxorubicin may also experience some damage to their heart muscle. Coenzyme Q10 is a vitamin-like substance that helps cells convert the sugars in our food into energy that muscles can use. Researchers believe that Coenzyme Q10 may help to protect against heart damage during doxorubicin treatment. The goal of this trial is to study the safety and effectiveness of Coenzyme Q10 when taken during treatment with doxorubicin. To be eligible for this trial, participants must be scheduled to receive at least four cycles of doxorubicin.
This is a Phase I trial

Exercise and Counseling to Prevent Lymphedema

Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection (NCT00376597)

Summary

A personalized exercise program, counseling, and education materials may be more effective than education materials alone in preventing lymphedema in women with breast cancer who are undergoing axillary lymph node dissection. This randomized clinical trial is studying how well education with or without exercise and counseling works in preventing lymphedema in women with stage I-III breast cancer who are undergoing axillary lymph node dissection.

Integrating Complementary and Standard Cancer Care

Breast Cancer Integrative Oncology: Prospective Matched Controlled Outcomes Study (NCT01366248)

Summary

Complementary and Alternative Medicine (CAM) is defined as medical and health care systems, practices, and products that are not thought of as standard care. Integrative Oncology (IO) is an approach to cancer care that combines conventional treatments with CAM therapies that have been found to be safe and effective in high-quality studies. The purpose of this study is to look at the use of CAM and IO in community settings and to investigate the effect that these therapies have on breast cancer patients' quality of life and risk of recurrence. To be eligible, participants must be receiving their care at a participating clinic in Washington state.

Effect of Omega-3 Fatty Acids Given Before Surgery on Breast Cancer Cells

A Randomized, Placebo-Controlled Phase II Clinical Trial of Omega-3 PUFA Dietary Supplementation in Patients With Stage I-III Breast Carcinoma (NCT01869764)

Summary

Omega-3 fatty acids are essential nutrients for good health. They are not made by the body, and are obtained only through foods or supplements. Laboratory studies suggest omega-3 fatty acids can slow the growth of cancer cells. This study is comparing the effect of omega-3 fatty acids to the effect of a placebo on breast cancer cells. To be eligible, participants must be planning to have breast cancer surgery (lumpectomy or mastectomy) at least 7 days from the start of the study.
This is a Phase II trial

Acupuncture for Chronic Lymphedema

Acupuncture for Chronic Lymphedema: A Randomized Wait-list Controlled Trial (NCT01706081)

Summary

Breast cancer treatment can result in lymphedema, a painful swelling of the arm or hand. It can develop right after breast cancer treatment or weeks, months or even years later. A small, preliminary study conducted by these researchers found that more than one-third of the 33 patients studied had at least a 30 percent reduction in lymphedema following acupuncture treatment, with no serious side effects occurring during the study or in the six months after treatment ended. This study, which is enrolling a larger group of patients, will allow the researchers to continue to study if acupuncture can reduce lymphedema and how long the effects last after acupuncture treatments ends. To be eligible, participants must have lymphedema for at least 6 months and no more than 5 years.
This is a Phase II trial