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Complementary and Alternative Medicine

Complementary and alternative medicine (CAM) may have a role in breast cancer care after a breast cancer diagnosis. Clinical trials are investigating which CAM therapies are effective during treatment or can improve quality of life for breast cancer survivors.

Melatonin to Reduce Fatigue Caused by Radiation Therapy

Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy: A Double Blind Placebo-Controlled Trial (NCT02332928)

Summary

Fatigue is a common side effect of radiation therapy. Melatonin is a hormone made naturally by the body that helps regulate sleep and wake cycles. Researchers think giving melatonin supplements to women before, during, and after their radiation therapy may help reduce fatigue. This study is comparing the effectiveness of melatonin supplements to a placebo in women receiving radiation as part of their breast cancer treatment.


This is a Phase III trial

A Diet Restricting Methionine in Early Stage Triple Negative Breast Cancer

A Window of Opportunity Study of Methionine Deprivation in Triple Negative Breast Cancer (NCT03186937)

Summary

To take part in this study, you must have recently been diagnosed with triple negative (ER-/PR-/HER2-) breast cancer and not yet had surgery or any other cancer treatments. This study is investigating the effect of reducing the amount of an amino acid called methionine in your diet has on cancer cells. High methionine foods include nuts, beef, lamb, cheese, turkey, pork, fish, shellfish, soy, eggs, dairy, and beans. Laboratory studies suggest reducing methionine levels can slow cancer cell growth. The cancer cells will be studied after they are removed during your breast cancer surgery.


This is a Phase II trial

Effect of Olive Oil on Breast Density in High-Risk Women

A Pilot Study of Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention In Women At High Risk Of Breast Cancer (NCT02068092)

Summary

Studies have shown that women with dense breast tissue are at increased risk for developing breast cancer. Laboratory studies have found that hydroxytyrosol--a major component of olive oil--is a powerful antioxidant with very low toxicity in the human body, even at high doses. Researchers think that hydroxytyrosol may reduce dense breast tissue. This study will evaluate the effect that hydroxytyrosol has on the breast tissue of women who are at high risk for developing breast cancer.


This is a Phase II-III trial

Mindfulness Meditation & Survivorship Education After DCIS & Stage I-III Breast Cancer

Improving Outcomes for Younger Breast Cancer Survivors: A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer Survivors (Pathways to Wellness) (NCT03025139)

Summary

To take part in this study, you must be have been diagnosed with DCIS or stage I, II, or III breast cancer within the last five years. Your diagnosis must have occurred when you were age 45 or younger. You must also show symptoms of depression on the study's screening questionnaire. This study is comparing the benefits of mindfulness meditation and survivorship education for reducing symptoms of depression in women who were diagnosed with DCIS or stage I, II or III breast cancer before age 45. Mindfulness meditation may help you change the way you respond to thoughts and life events. Survivorship education tailored to younger survivors may help help reduce stress and improve well-being and quality of life.

A Study of Metastatic Breast Cancer Patients Receiving Integrative Oncology

The Canadian/US Integrative Oncology Study (CUSIOS): Advanced Integrative Oncology Treatment for Patients With Advanced Stage Cancer: A Prospective Outcomes Study (NCT02494037)

Summary

Up to 80% of cancer patients in the U.S. receive some form of complementary or alternative medicine. Some patients are treated by naturopathic doctors who are board certified in naturopathic oncology or by traditional Chinese medicine providers with advanced training in oncology. This level of care is often called advanced integrative oncology (AIO). Little is known about the benefits AIO may add to cancer care. This study will follow patients with advanced breast (and other) cancer who are also receiving AIO and compare their outcomes to outcomes that would be expected based on findings from other studies. To be eligible, participants must be starting to receive care at a participating Integrative Oncology center.

Online Mindfulness-Based Stress Reduction for Metastatic Breast Cancer Patients

RCT of Online Mindfulness-Based Stress Reduction for Metastatic Breast Cancer Patients (NCT03683147)

Summary

To take part in this study you must be a woman who was diagnosed with metastatic breast cancer within the past five years and is currently receiving treatment at the Roswell Park Cancer Institute in Buffalo, New York. This study is evaluating an online mindfulness-based stress reduction treatment. Patients can enroll if they have a distress score of 4+, have an internet connection, and are not currently seeing a psychologist.

Yoga for Chemotherapy Induced Peripheral Neuropathy in Survivors

Yoga for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Pilot Study (NCT03292328)

Summary

To take part in this study, you must be a breast cancer survivor and have moderate to severe peripheral neuropathy (numbness and pain in hands and feet) caused by your chemotherapy treatment. It must also be at least three months since you completed chemotherapy. This study will see if a yoga program reduces the pain and numbness in the hands and feet (peripheral neuropathy) that can be caused by certain types of chemotherapy.

Plant-Based Nutrition for Women with Metastatic Breast Cancer

Whole-Food, Plant-Based Nutrition Among Women With Metastatic Breast Cancer: A Pilot Study of Recruitment, Retention, and Preliminary Changes in Biomarkers and Symptoms. (NCT03045289)

Summary

To take part in this study, you must have stable stage IV metastatic beast cancer and have had at least one imaging test (CT scan, bone scan, or PET/CT) within the last 6 months. You must also currently be receiving a systemic therapy. This study is investigating the effects (good or bad) that a whole-food, plant-based diet has on women with stable metastatic breast cancer who are currently receiving treatment.

Effects of Hypnosis During Breast Cancer Surgery

Biobehavioral Effects of Hypnosis During Breast Cancer Surgery (NCT03012399)

Summary

To take part in this study, you must have recently been diagnosed with DCIS or stage I breast cancer and be planning to have breast surgery. This study is investigating a relaxation method called hypnosedation. Using this technique before and during breast cancer surgery may allow patients to avoid having general anesthesia. Hypnosedation is administered by a hypnotherapist, a mind-body specialist who uses words and images to help you relax during surgery.

Acupressure for Chinese Immigrant Breast Cancer Survivors in Los Angeles

Acupressure Intervention to Improve Fatigue and Physical Functioning of Chinese Immigrant Breast Cancer Survivors (NCT03091647)

Summary

To take part in this study, you must be a first-generation immigrant who speaks Chinese (Mandarin or Cantonese) living in or near Los Angeles, California. You must have been treated for DCIS or Stage I, II, or III breast cancer within the last 1 to 5 years and have moderate to severe levels of fatigue. This study is investigating whether using a Chinese-language video to teach patients how to self-administer acupressure helps improve cancer-related fatigue and quality of life better than the current standard of care.

Acupuncture for Relieving Severe Post-Mastectomy Pain

Randomized-Controlled Trial of Acupuncture for Post-Mastectomy Pain Syndrome (NCT02754752)

Summary

To take part in this study, you must have had a mastectomy at least 4 months ago. You must also have had persistent pain in your chest area for at least 3 months. In addition, you must have seen your oncologist within the last 6 months. Electro-acupuncture is a two-step process. First, hair-thin needles are put into specific points in your body. Then, a mild electrical current is applied to the needles at a level that is comfortable to you. This study is investigating whether electro-acupuncture can help reduce pain women may experience after their mastectomy.


This is a Phase II trial